Transcriptomics mIF Solution

Stereo-seq mIF Product Note Stereo-seq Permeabilization Set User Manual Stereo-seq Transcritpomics Set for mIF User Manual

Solution Overview

Combing whole transcriptomics, protein detection, and tissue morphological information on the same tissue section allows for in-depth spatial multi-omics discovery. Studying cellular heterogeneity empowers the discovery of new biomarkers, identifying the cellular origin of important expressed proteins within healthy and abnormal tissue microenvironments. It also further advances immuno-oncology research by studying how immune cells respond to tumor development, and what are the genes and proteins that are involved in the regulation processes.

Stereo-seq transcriptomics mIF solution enables spatial visualization of multiple proteins in single-cell resolution on top of the unbiased whole transcriptome information on the same tissue slice. Without affecting mRNA capturing, the additional detected protein information can be integrated with gene expression data to in-depth evaluate valuable samples, and to parse complex pathological and physiological processes.

Product Highlight

High fidelity protein staining imaging for enhanced spatial protein identification

Detect multiple proteins with unbiased whole transcriptome simultaneously in fresh frozen and PFA fixed samples.

Flexibility in choosing antibodies based on user's research needs and project design.

Co-detection of protein and RNA in a single experiment for extensible applications in tissue and cellular type study.

Key features

Demo Data

Mouse testis

Section size: ~16.3 mm²
Number of mapped spatial barcodes (CIDs) under tissue: ~29.5 M
Number of genes: 356 (bin 20, 20 × 20 DNB)

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Workflow