Go Optical - STOmics

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Go Optical

Go Optical is a STOmics microscope manufactured by MGI, specifically designed to meet the imaging needs of Stereo-seq workflows. It employs multiple illumination techniques to capture high-resolution images with minimal stitching errors, making it ideal for tissue segmentation in Stereo-seq applications.

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Function Overview

STOmcis go optical key Features and Functionalities

Panoramic scanning imaging of
biological tissue sections

Objective lens
4×, 10×, 20×, (40×)

Epi-illumination and
Trans-illumination mode

Supports chips up to
69mm × 69mm in size

Epi-fluorescence,
Epi-bright field
& Transmitted bright field

Fluorescence channel
DAPI, FITC, TRITC, CY5

Product Highlight

High resolution

High-resolution, low-stitching images from Go Optical enable accurate identification of trackline and tissue details, realizing tissue and single-cell segmentation—ideal for Stereo-seq’s high-resolution spatial data.

Large scanning range

Go Optical offers a large travel range of 100mm × 70mm, meeting the scanning needs of most STOmics large chips and supporting imaging of various tissue types, such as mouse embryos and monkey brains.

Fast image

Go Optical’s auto-focus detection simplifies photography process, allowing for scanning of a 1cm x 1cm chip under 10X objective lens in just ≤70s, effectively preserving the integrity of the sample's RNA.

Experimental Process

Images captured by Go Optical can be analyzed using algorithms and aligned with transcriptome data to achieve tissue segmentation.

Go Optical delivers high-resolution imaging with minimal stitching errors, perfectly compatible with spatial transcriptomics image registration workflows.

Achieving Single-cell Level Analysis with CellBin

The CellBin algorithm intelligently identifies and defines cell boundaries in tissue-stained images. It simultaneously segments both the images and captured transcriptomic information based on these boundaries, enabling single-cell level clustering and the acquisition of high-resolution spatial transcriptomic maps. Precise single-cell segmentation relies on high-definition imaging and accurate stitching by microscopes, which the spatiotemporal microscope is fully capable of delivering.

Performance and System Parameter

Performance Parameter

Go Optical
Optical System	Positive fluorescence microscope
Objective Lens	4X, 10X, 20X, (40X) universal motorized objective lens converter, support expansion
Observation Methods	Epi-fluorescence, Epi-bright field, Transmitted bright field
Travel Range X&Y	100 mm x 70 mm
Fluorescent Channel	Standard configuration: DAPI, FITC, TRITC, CY5, and supports optional configuration of other dye filter blocks
Auto-focusing	Two optional modes——Auto-focus mode and map navigation mode
Working Efficiency	Scanning 10mm x 10 mm under 10X objective lens, scanning time≤70 s
Working Mode	Manual operation by human eye observation; fully automatic scanning and imaging.

System Parameter

Power & Dimensions & Weight

Working Environment

Voltage: ~220 V

Rated Power: 300 VA

Dimensions (W x H x D): 400 mm (L) x 334 mm (W) x 726 mm (H)

Weight: ~36 kg

Temperature: 5℃~40℃

Humidity: 30% RH to 75% RH, with no condensation

FAQ

Q What are the main application scenarios in spatiotemporal omics? + -

The Go Optical is primarily designed for various application scenarios within spatiotemporal omics, including:

1）Fluorescence imaging mode for capturing fluorescence-labeled silicon chip samples；

2）Brightfield imaging mode for capturing pathology-stained silicon chip samples；

3）Transmission brightfield imaging mode for capturing pathology-stained glass slide sample.

Q What certifications does the Go Optical have? In which areas can it be sold? + -

The Go Optical has currently obtained RUO-CE and RUO-NRTL certification, allowing to be sold in such as China, North America, the EU and Asia -Pacific.

Q What are the main components of the STOmics Microscope Go Optical? + -

Go Optical incuding 2 parts, hardware and software. The hardward comprises a microscope, an electronic control box, a computer host, and a display monitor. 2 softwares are Scanncer and Tiff Browser.

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