Go Spatial - STOmics

Go Spatial: STOmics Automated Sample Preparation System

Go Spatial is MGI's dedicated automated laboratory instrument for Stereo-seq spatial transcriptomics workflows. Designed for post-imaging sample preparation, it automates the full process from post-imaging to cDNA collection, supporting both fresh-frozen (FF) and FFPE tissue types. As a sequencing-based platform, Go Spatial makes Stereo-seq transcriptomics experiments both standardized and scalable.

Product Highlight

Flexible Throughput

FF workflow: 2–12 chips per run (up to 12 cm^2 ). FFPE workflow: 2–8 chips per run (up to 8 cm^2 ). Scalable to meet diverse experimental needs.

Full Process Automation

Achieves a breakthrough in automating the process from post-imaging to cDNA recovery. Greatly reduces manual operation steps, lowers operational complexity, and minimises the risk of human error.

Easy to Operate

User-friendly graphical control software enables operators to get started after simple training. An intuitive human–computer interaction platform streamlines every step

Reliable & Robust

Independent 8-channel pipetting with individual control modes ensures high precision, high repeatability, and effectively reduces batch-to-batch variation.

Product Features

Pipette Precision (5–50 µL range)

Intra-batch Stability (Pearson R, same instrument)

Inter-batch Stability (Pearson R, across instruments)

Consistency vs. Manual (Mouse thymus, Pearson R)

Workflow

Reliable and Trustworthy Output

Full throughput validated: 8 chips from one OMNI V1.1 FFPE workflow. CV (Bin50) < 15% across all chips. In mouse brain samples (~480M total reads), Go Spatial produced a higher Bin20 Median Gene count (223 vs. 206 for manual), demonstrating automation does not compromise data quality.

Spatial clustering patterns across four mouse tissue types (testis, liver, thymus, brain) are virtually indistinguishable between manual and Go Spatial runs.
Mouse thymus Pearson R = 0.999. Comparable QC metrics including MID count, gene count, duplication rate, and tissue coverage observed across all tissue types.

High Compatibility with No Limit on Species and Tissue Types
Go Spatial supports both fresh-frozen and FFPE samples and is species agnostic. A wide range of sample types have been validated.

Demo Data

Advance towards a more accurate and in-depth saptial single-cell omics study with Stereo-seq's robust chemistry and efficient bioinformatics tools.

Go Spatial Mouse Embryo Demo Data

Go Spatial Mouse kidney Demo Data

Go Spatial Module components

FAQ

Q What reagent kits are required for Go Spatial experiments？

For FF samples: the Stereo-seq Transcriptomics Set V1.3 for Go Spatial (Cat. No. 411ST13114), which includes the Transcriptomics T Kit, Chip T Slide, and Accessory Kit FF V1.3. For FFPE samples: the Stereo-seq OMNI Transcriptomics FFPE Set V1.1 (Cat. No. 411SN11114), which includes the Transcriptomics N Kit, Chip N Slide, and Accessory Kit FFPE V1.1. Additionally, a 16 Barcode Library Preparation Kit V1.1 (111KL11160) is required for library construction. Items labeled “-CG” are for US region only.

Q What certifications does Go Spatial have？

Go Spatial holds RUO certifications including CE, UKCA, EAC, and NRTL, allowing it to be sold and used in regions including the EU, UK, Eurasia, and North America. It is intended for Research Use Only (RUO) and is not for use in diagnostic procedures.

Q How does Go Spatial compare to manual operation in data quality？

Go Spatial demonstrates 99.9% consistency with manual workflows (mouse thymus, Pearson R = 0.999). Spatial clustering patterns and gene expression profiles are virtually indistinguishable between manual and Go Spatial runs across four mouse tissue types. In mouse brain samples (~480M total reads), Go Spatial produced comparable or higher data metrics than manual processing.

Q What tissue types and species can Go Spatial process？

Go Spatial supports all tissue types and all species with no limitation. It is compatible with both fresh-frozen （FF） and FFPE tissue samples. Validated examples include mouse brain, liver, thymus, testis, embryo, spleen, kidney, and tongue; human lung cancer, pancreatic cancer; monkey intestine; and numerous human FFPE tumor types including esophageal, cervical, prostate, lung, bowel, renal, ovarian, and gastric cancer tissues.

Q What is the throughput and annual capacity of Go Spatial？

Go Spatial supports 2–12 chips per run for FF samples (6 slides × 2 chips) and 2–8 chips per run for FFPE samples (4 slides × 2 chips). With staggered scheduling, FFPE annual capacity is estimated at ~1,200 chips/year (50 wk × 3 runs/wk × 8 chips), and FF (known permeabilization time) at ~1,800 chips/year. All figures assume 1 technician and are validated by MGI R&D.

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