Paper Review

Recently, Cell presented the latest annual "Best of Cell" series featuring 12 articles published throughout 2024, Cell's 50th anniversary year. The paper titled "3D reconstruction of a gastrulating human embryo" was honored with inclusion in this list, which generated an in-depth and high-resolution 3D spatial transcriptomic dataset of a human CS8 embryo, providing a natural embryo reference for future study.

Researchers in this study used Stereo-seq on 62 transverse slices with one slice interval that covered a fully intact gastrulating human CS8 embryo from the anterior to the posterior side. Researchers annotated cell lineages by integrating gene expression patterns and spatial information, identified a potential signaling center at the posterior end of the human embryo, and investigated the dynamic activity of signaling pathways along the embryonic body axis. The comprehensive 3D transcriptome dataset (website: https://cs8.3dembryo.com/#/home)offers an opportunity to explore the fundamental cellular and molecular features of gastrulation in humans. It serves as a cornerstone for the development of advanced stem-cell-derived human embryo models.

Learn more about the research: https://www.cell.com/cell/abstract/S0092-8674(24)00357-X?dgcid=raven_jbs_aip_email

About STOmics Stereo-seq:

STOmics now presents the upgraded Stereo-seq Transcriptomics Solution v1.3, featuring refined reagent chemistry, enhanced probe design and optimized enzyme selection. This version delivers enhanced capture efficiency, broader compatibility, and a more streamlined workflow while minimizing the diffusion of mRNA molecules to achieve accurate spatial single-cell-level analysis.
Find out more about STOmics Stereo-seq? https://en.stomics.tech/products/stereo-seq-transcriptomics-solution/list.html